Karen
| Real Name: | Karen |
| Birth Year: | 2017 |
| First Appearance: | Spider-Man: Homecoming |
| Team Affiliation(s): | Stark Industries The Avengers Team Iron Man |
| Race: | Artificial Intelligence |
| From: | New York, NY |
| Height: | N/A |
| Weight: | N/A |
Karen was a natural-language user interface created by Tony Stark and installed in the second iteration of the Spider-Man Suit. It was designed to work alongside and aid Peter Parker in his duties as Spider-Man provided that the young hero completed the Training Wheels Protocol. Following Mysterio's attacks in Europe, the Stark Spider-Man suit was destroyed, eliminating Karen as well.
Karen's AI is integrated into Spider-Man's suit which essentially creates a fully-loaded Spidey version of Iron Man, complete with 576 different combinations of web-slinging options and other high-tech gadgetries. There's also a soothing female voice that communicates all information — both good and dire — to Peter.